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Explore our FDA-focused solution areas to see how we support medical device and pharmaceutical companies across regulatory pathways and product types, from early strategy through approval-ready submissions.
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BSC® Insights
Do you know that many aspects of sleep and circadian behavior are heritable?
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1 min read time
Do you know that many aspects of sleep and circadian behavior are heritable both in humans and mice?
In this new article, Brendan Keenan, in collaboration with the School of Medicine, University of Pennsylvania, has published an article on high-throughput phenotyping strategies for sleep and circadian behavior in mice, including examinations of robustness, reliability, and heritability among Diversity Outbred (DO) mice in the Sleep Research Society.
The article "High-throughput sleep phenotyping produces robust and heritable traits in Diversity Outbred mice and their founder strains" discuss sleep-related phenotypes that can be used to discover genetic associations in DO mice. This provides the basis for future studies to identify gene variants and complex genetic effects that influence sleep and circadian behavior using DO mice.
Interested in understanding more about how they developed the high-throughput pipeline? Check this article: doi: 10.1093/sleep/zsz278
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